Do Women Have a Favorable Advantage with Mesothelioma?

Woman symbolA new study of mutations that are gender-specific was found for the first time in a research study at the Women’s Hospital at Brigham International Mesothelioma Program (IMP). Research has shown that typically, women have better outcomes and a higher chance of survival than men with comparable diagnoses. The first step towards developing adequate treatments for those suffering from mesothelioma is to identify the various mutations and why women have the favored position when diagnosed.

Gender-Specific Outcome Study

The study called, Gender-Specific Molecular & Clinical Features Underlie Malignant Pleural Mesothelioma, conducted by a doctor at the Thoracic Surgery Oncology Lab at Brigham Women’s Hospital (BWH). The research revealed that molecular variations may explain the gender-specific outcomes noticed in women and men. Observations from the research included TP53 mutations which are culprits in several types of cancers yet not so much in cases involving mesothelioma. In cases where the TP53 mutations were discovered they were twice as likely to be found in female patients compared to their male counterparts. Additionally, results indicated reduced rates of the BAP1 mutation seen in non-epithelioid masses, a histological subtype known for poor prognoses. To fully understand these mutations, one may want to look for mutated genes in multiple patients as well as noticing groups of commonly mutated genes which work together along “molecular pathways” within the cancerous cells.

Do Women Have an Advantage Genetically?

Investigating the differences amongst these mutations in women and men is essential when learning the ways we can differentiate and create more personalized medical care. Determining whether women have an advantage genetically based on properties of molecular tumors includes recognizing their specific mutations to answer this question: Is there something we can learn about these cancerous genes that are in women to help us improve mesothelioma treatments for men? Analyzing the tumor genome and documenting the genetic differences allows one to see how the mutations interact with each other. This will improve and provide new approaches for specific therapies.

Survival Rates

The five-year survival rate for women is estimated at 22% and 9% for men. The difference stretches even more when you are studying the numbers of patients that are younger than 50-years-old.

The cutting-edge assessment of mutations that are gender-specific may lead to more personalized treatments that will aid and advance the results for all men and women.

Mesothelioma Occurs More Often in Men

Research indicates about 3,000 people are diagnosed annually with mesothelioma in our country. Mesothelioma occurs more frequently in men than women. The median age for a diagnosis of pleural mesothelioma is 69.

The rate of mesothelioma diagnoses is no longer increasing as it used to. It now may be decreasing now that we know more about its origin. The average survival rate is defined as the length of time that a person can survive after the cancer is diagnosed. For patients with pleural mesothelioma who are unable to undergo surgery, the average survival time is one year.

Prognosis Depends on Many Factors

Two important factors of how long a patient may live after being diagnosed depends on the age and type of mesothelioma. For example, patients diagnosed with peritoneal mesothelioma have a slow growing tumor and usually live longer.

Sacramento Mesothelioma Lawyers
Edward A. Smith

I'm Ed Smith, a Sacramento mesothelioma attorney. If you or a member of your family has been diagnosed with Mesothelioma, please call me at (916) 921-6400 or toll free at (800) 404-5400 for free, friendly advice.

I’ve been helping people recover compensation for their personal injury and wrongful death claims since 1982.

I am a Million Dollar Advocate. This is a group of top U.S trial lawyers with multiple million dollar case settlements and verdicts.

See my past verdicts and settlements here.

Read my client reviews at Avvo, Google Plus and Yelp.

Image Attribution: Own Work Ryoga~2003 [Public domain images], via Wikimedia Commons

:LLO/bw

Client Reviews
  • Me and my wife; had a car accident. We were amazed how easy, professional, friendly attorney Ed Smith is along with his staff. Everybody is amazing. Thank you so much, we are very impressed!
    Sincerely, Alex & Dinah M. ★★★★★
  • Ed Smith and his office team took on a difficult personal injury case on my behalf and for the passenger in my car. Ed is a top- notch attorney. His staff couldn't have been more helpful and kind. No need to look elsewhere. I give Ed Smith my highest recommendation. Beverly ★★★★★
  • Ed and Robert have been taking great care of my husband and I for the past 5+ years. They are always there when you have a problem and a quick resolution! Even when the issues have nothing to do with them. They are willing to help ease the pain off your shoulders. They are as good as it gets! Thank you again for everything. Annie T. ★★★★★
  • Very professional. Great team, staff and service all around. Mr Smith was very honest, straight forward with his advice. He gives the word "attorney" an honest reputation. I will seek his council anytime, and would recommend him at the drop of a dime. Jeremy M. ★★★★★
  • I would highly recommend Ed Smith to any friends or family in need of a personal injury attorney. Ed, and his staff, are very caring on top of being very experienced in this field. The staff always keeps you informed of the status of your case and they are always easy to reach by phone. Shannon D. ★★★★★
  • Edward Smith law offices provide competent, thorough, and personable help for victims of personal injury. When you first meet the staff you know you contacted the right office. This law office treats clients like people. I recommend this office to anyone seeking representation regarding personal injury. David M. ★★★★★